Loco Regional Hyperthermia (LRHT) is a method for non-invasive treatment of primary cancer and its metastases or for prevention of relapse of a cancer disease comprising administering an immune stimulant to a patient in association with radiofrequency waves using capacitive coupling in a condenser arrangement
AN IN-SITU AND IN VIVO VACCINATION METHOD FOR TREATMENT OF PRIMARY CANCER AND ITS METASTASES EVEN IN DISSEMINATED CELL STATES
AND FOR ENABLING AND SUPPORTING THE PATIENT’S OWN IMMUNE SYSTEM TO RECOGNIZE AND KILL THE CANCER CELLS AND TO BUILD UP A MEMORY TO PREVENT RELAPSE OF A CANCER DISEASE.
Hyperthermia: The immune system’s ally in the battle against cancer. “Our immune system knows how to fight such diseases as cancer. Inside our lymph nodes, T-cells are activated against cancer cells. This happens with the help of surface receptors. But to prevent overreactions of T-cells, these immune cells also express programmed cell death protein 1, PD-1.”
This video explains how hyperthermia promotes immunobiological effects, thus supporting the human body in its fight against tumors. This 3D animation video has been developed, directed and produced by Monica Sennewald. The scientific support was provided by Professor Dr. Udo Gaipl of Universitätsklinikum Erlangen and the graphic animation was realized by Gebrüder Betz in Berlin.
Loco Regional Hyperthermia (LRHT) is based on the classical method of Hyperthermia (high-heat) but does more than just randomly heat layers of tissue. mEHT employs a modulated electric field to selectively deliver a controlled energy dose to a localized treatment area. A mobile electrode is positioned on the treatment area, while a second stationary electrode remains in a fixed position below the patient, integrated within the therapy bed. Operating at a carrier frequency of 13.56 MHz, this capacitive coupled impedance balancing circuit delivers controlled energy directly to the malignant cells.
Microbiological tests have demonstrated that higher ionic concentrations exist in the more active malignant cellular environment. Consequently, the extracellular matrix of malignant tissue inherently has greater conductivity and permittivity than healthy tissue. This difference facilitates selective focus on malignant cells even in highly mixed tissue containing large numbers of healthy and malignant cells. The derived advantage is the RF field tends to flow predominantly through the tumour tissue where concentration of the focused field and the associated energy absorption heats the malignant cells.
This process of natural selection is further enhanced by the electric-field modulation, which addresses the autonomous, non-collective behavior of individual malignant cells by reengaging the body’s inherent immune response. Ultimately, malignant cells are then driven to achieve “apoptosis”.
This effect of modulated electric field is unique and exclusive to therapy with the Oncotherm device.
Can LRHT be combined with other forms of treatment?
Loco Regional Hyperthermia (LRHT) is intended for use as an adjunct to chemotherapy and radiotherapy, and is devoted to the non-invasive hyperthermia based treatment of indicated solid tumour cancers. LRHT has proven to be complementary to these treatments by enhancing the beneficial effects of chemotherapy and radiation while helping to mitigate side effects. Even a tumour which has developed a resistance to chemotherapy and radiation, may respond again to these therapies following LRHT treatment.
Are there any adverse side-effects to LRHT?
Loco Regional Hyperthermia (LRHT) is a complementary therapy that presents minimal risk and limited adverse side effects. Heating the tumour has minimal effect on adjacent healthy tissue; however, some slight surface skin reddening can occur. This effect is mitigated through regular patient communication during treatment. Also, the body’s natural circulation is extremely efficient and soon dissipates the heat – something the tumour is not capable of because of its more primitive blood supply.