Herbal Helpers: Calendula and Prevention of Radiation-Induced Oral Mucositis

Herbal Helpers: Calendula and Prevention of Radiation-Induced Oral Mucositis

Radiation therapy for head and neck cancers is often complicated by oropharyngeal mucositis—a painful and sometimes treatment-limiting side effect. In this randomized controlled clinical study, Babaee and colleagues explored whether an extract of Calendula officinalis flowers, known for their antioxidant and anti-inflammatory properties, could help prevent or reduce the severity of this condition. A total of 40 patients undergoing radiotherapy were randomized to either receive calendula extract as an oral rinse or a placebo rinse throughout the course of their treatment.

The study found that patients in the calendula group experienced significantly lower rates and severity of mucositis compared to those in the placebo group. Using the World Health Organization mucositis scale, the researchers reported that only 15% of patients in the calendula group developed grade 3 mucositis, compared to 65% in the placebo group (p < 0.001). Additionally, calendula was associated with lower pain scores and improved ability to eat and drink, pointing to better preservation of quality of life during radiotherapy.

Laboratory testing supported these clinical findings: calendula extract demonstrated strong antioxidant activity, suggesting that its protective effects may stem from reducing oxidative stress and inflammation in oral tissues exposed to radiation. Importantly, no adverse effects from calendula were reported, highlighting its safety and tolerability.

Overall, this trial provides evidence that Calendula officinalis flower extract can be a safe, natural, and effective intervention for preventing or minimizing radiation-induced oropharyngeal mucositis in patients with head and neck cancers. By reducing both the incidence and severity of mucositis, calendula may help patients better tolerate cancer treatment while maintaining comfort and nutrition.

References

Babaee N, Moslemi D, Khalilpour M, et al. Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: a randomized controlled clinical study. Daru. 2013;21(1):18

By Dr. Sydney Moffat, ND and Dr. Gurdev Parmar, ND, FABNO(USA)